USP8 PROMOTES THE TUMORIGENESIS OF INTRAHEPATIC CHOLANGIOCARCINOMA VIA STABILIZING OGT

Abstract Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development.Herein, we identified Ubiquitin-specific read more peptidase 8 (USP8) as a key regulator for promoting the tumorigenesis of iCCA cell via stabilizing OGT.USP8 was overexpressed in human tumor tissues and correlated with worse survival

Hairy vetch (Vicia villosa Roth) and smooth vetch (V.villosa Roth var.glabrescens) are important cover crops and legume forage with great economic and ecological values.Due to the large and highly heterozygous genome, full-length transcriptome reconstruction is a cost-effective route to mining their genetic resources.In this study, a hybrid sequenc